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                                    Acetylspiramycin Tablets manual
General name: Acetylspiramycin Tablets
English Name: Acetylspiramycin Tablets
Chinese phonetic alphabet: Yixian Luoxuanmeisu Pian
[ingredients] this product is single Acetylspiramycin II, Acetylspiramycin, diacetyl spiramycin II III
And diacetyl spiramycin III four component based mixture.
[chemical structure]

[character] this product is a sugar coated piece. After the coating is removed, it is white or yellowish.
Adaptation to mild, moderate, and moderate Streptococcus, Streptococcus and Streptococcus pneumoniae
Infection, such as pharyngitis, tonsillitis, sinusitis, otitis media, periodontitis, acute bronchi
Acute attack of inflammation, chronic bronchitis, pneumonia, nongonococcal urethritis, skin soft group
Infection, also used in cryptosporidiosis, or as a treatment for toxoplasmosis in pregnant women
The choice of drugs.
[Specification] 0.1g (100 thousand units)
Adult dose: 0.2 to 0.3g once, 4 times a day, doubling for the first time.
Child dose: 20 to 30mg/kg per day, 4 times.
The patients were well tolerated and the main adverse reactions were abdominal pain, nausea, vomiting and other stomach.
Intestinal reaction, often occurring at large doses, is mostly mild, and can be taken after withdrawal.
The line disappears. There are few allergic reactions, mainly drug rash. No impairment of liver and kidney function and
Abnormal blood and urine.
[taboo] is forbidden in patients with allergy to this product, erythromycin and other macrolides.
[note] 1. as the hepatobiliary system is the main pathway of Acetylspiramycin excretion, severe liver function
Not all patients are careful with this product.
2. patients with mild renal insufficiency need not be adjusted for dose, but acetyl spiramycin is serious
The use of renal insufficiency still lacks data, so it should be used carefully.
3. if there is an allergic reaction, stop the drug immediately.
The efficacy and safety of pediatric patients within 6 months have not been determined.
The elderly patients with normal liver and kidney function do not need to be reduced.
[drug overdose] is not yet clear.
[pharmacologic toxicology] acetyl spiramycin is an acetyl derivative of spiramycin, which belongs to 16 membered ring macrolides.
This product is used for Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, and Enterococcus faecalis
Positive gram positive cocci have good antibacterial effect. Lester, Mora M. genus of bacteria,
Neisseria gonorrhoeae, Campylobacter foetus, Haemophilus influenzae, Legionella pneumophila, pertussis
Bacilli, bacteriobacterium, bacilli, Propionibacterium acnes, digestive coccus and elimination
Streptococcus and chlamydia, mycoplasma, toxoplasmosis and Cryptosporidium are also inhibited.
The effect of the system. Gram-negative bacilli in intestinal tract are usually resistant. The mechanism of action is acetyl spiramycin
Binding to the ribosome 50S subunit of sensitive microorganisms and inhibiting the protein dependent on RNA
Synthetic and bacteriostasis.
(storage) sealed in a cool and dark (not more than 20 degrees centigrade) dry place
[packaging] aluminum plastic packaging, 12 pieces per plate, 2 plates per box.
[period of validity] 24 months
The two part of the 2005 edition of the Chinese Pharmacopoeia
[revision date] May 28, 2007
Enterprise name: Heilongjiang ha star Pharmaceutical Group Co., Ltd.
[] Pregnant and lactating women use this product can penetrate the placenta, the application need to fully weigh the pros and cons in pregnant women
Then decide whether or not to apply. There is no data to show whether acetyl spiramycin is
It is excreted by milk, but because many macrocyclic ester drugs can be treated with milk
It is necessary to use this product carefully for breast-feeding women, if they must be applied.
Breastfeeding is suspended.
[pharmacokinetics] this product is acid resistant, absorbs well orally. After absorption of the stomach and intestines, the deacetyl group is transformed into a spiral
Mycophentin plays an antiseptic effect. The concentration of blood drug peak (Cmax) was reached 2 hours after a single dose of 0.2g
1mg/L. This product is widely distributed in the body and is secreted in bile, urine, pus, and bronchus
The concentration in the body, the lung tissue and the prostate is generally higher than the blood concentration, and this product can not pass through the blood -
The cerebrospinal fluid barrier (CSF). The average half-life of blood elimination (t1/2 beta) was about 4~8 hours. Multiple drug delivery
After accumulation. This product is excreted mainly by feces, and the urine excretion is about 12 hours.
5% to 15% of the dosage was given, most of which were metabolites, and the concentration of bile in the bile could reach the concentration of blood.
15~40 times the degree.
[drug interaction] 1. products do not affect the metabolism of aminophylline and other drugs in vivo.
2. in patients receiving ergoid derivatives, the use of certain large rings
At present, there was no acus and acetyl spiramycin in esters.
The effect is reported, but in theory there is still this possibility, so acetyl spirals
Mycin and ericin should not be taken at the same time.
Address: Hegang Road, Gongnong District Sanjing
Postcode: 154101
Phone number: 0468-3122833 0468-3122885
Fax number: 0468-3122805
Web site:
If there is any problem, contact with the production enterprise.


Heilongjiang ha xing Pharmaceutical Co., Ltd. all rights copyright
Tel:0468-3122885 0468-3122833

Fax:0468-3122805 Phone number:13339585089
Address: Hegang City, Heilongjiang Province, Gongnong District Sanjing Road

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